Original Research Article
Year: 2022 | Month: November | Volume: 9 | Issue: 11 | Pages: 380-385
DOI: https://doi.org/10.52403/ijrr.20221151
A Comparative Study of Combined Effect of Dermaroller and Topical Tacrolimus (50 Cases) vs Topical Tacrolimus Alone (50 Cases) In Patients of Stable Vitiligo (Total 100 Cases)
Khyati Sidapara1, Deval Vora2, Prachi Mehta3, Nidhi Patel4, Ravindra Patel5
1,3,4Third year resident, Department of Skin, V. D. & Leprosy, Shri M.P. Shah Government Medical College, Jamnagar- 361008
2Professor and Head of department, Department of Skin, V. D. & Leprosy, Shri M.P. Shah Government Medical College, Jamnagar- 361008
5First year resident, Department of Skin, V. D. & Leprosy, Shri M.P. Shah Government Medical College, Jamnagar- 361008
Corresponding Author: Khyati Sidapara
ABSTRACT
Background: Vitiligo is an autoimmune disease produced as a result of interaction of environmental, genetic, neural factors, leading to the destruction of melanocytes and appearance of depigmented macules. It is a chronic disease of great cosmetic concern. As it is often recalcitrant to medical treatment alone, many surgical techniques are used to treat stable vitiligo.
Aims and objectives: To evaluate the efficacy and safety of combined dermaroller and topical tacrolimus versus topical tacrolimus alone treatment in the patients of stable vitiligo.
Materials and Methods:
- Material:Dermaroller specification :192needles, 1.5 mm diameter
- Method: Patients were randomly assigned into two groups of 50 patients each. Group A received treatment with dermaroller followed by topical tacrolimus whereas Group B received treatment with topical tacrolimus alone. In both the groups, standard medical treatment was also given. Standard digital photographs were taken at each visit to support the data.
Results: The dermaroller group showed maximum patients with excellent response in 44% cases as compared to topical tacrolimus alone group which showed excellent response in 24% cases.
Limitations: small sample size and absence of control group were the main limitations of our study.
Conclusion: Dermaroller is safe and effective tool for repigmentation in vitiligo with minimum side effects for transdermal drug delivery.
Keywords: Vitiligo, Dermaroller, Tacrolimus
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