Review Paper
Year: 2022 | Month: December | Volume: 9 | Issue: 12 | Pages: 95-108
DOI: https://doi.org/10.52403/ijrr.20221211
Ferrocenyl Benzimidazole: A Promising Molecule
Silpa Saji.S1, Namitha K.N2, Dr. Shaiju. S. Dharan3
1,2,3Department of Pharmaceutical Chemistry, Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Thiruvananthapuram, Kerala – 695124
Corresponding Author: Silpa Saji.S
ABSTRACT
Organometallic compound ferrocene formation was a serendipity and due to its "barrel-shape" which grants 3D geometry of the organometallic compound it has an optimal spatial design for better fitting and connection inside the pockets of the dynamic site in natural targets and receptors. The benzimidazole motif has developed to be a significant privileged heterocyclic platform. Ferrocenyl benzimidazole is a complex organic compound having ferrocene an organometallic compound attached to the 2-position of benzimidazole an aromatic heterocyclic compound. Ferrocene benzimidazole derivatives have attracted lots of attention for the construction of new compounds due to their wide applications. By combining ferrocene and benzimidazole produce a vast range of pharmacological actions. Synthetic method and pharmacological effects of various ferrocenyl benzimidazole derivatives were examined. This review gives the medicinal activities of 2- ferrocenyl benzimidazole derivatives like cytotoxic activity, anti-malarial, anti-microbial, anti-fungal etc. were furnished.
Keywords: ferrocene, benzimidazole, cyclopentadiene, 2-ferrocenyl benzimidazole, cytotoxic, anti-malarial.
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