Original Research Article
Year: 2022 | Month: January | Volume: 9 | Issue: 1 | Pages: 568-573
DOI: https://doi.org/10.52403/ijrr.20220166
Clinical Experience of Scrubs Typhus Patients in a Tertiary Care Hospital of Eastern India
Sarat Kumar Behera1, Sandesh Kumar Pattanaik2, Saiprasanna Behera3, Sudeep Kumar Patra4
1Senior Consultant Chest Physician and Critical Care Medicine Specialist, Amri Hospitals Bhubaneswar, AMRI Hospitals, Odisha-751025
2Clinical Research Coordinator, CRO Pharmatrendz Pvt Ltd, Bhubaneswar -751014. Odisha
3Research Director, CRO Pharmatrendz Pvt Ltd, Bhubaneswar -751014. Odisha
4Research Associate, CRO Pharmatrendz Pvt Ltd, Bhubaneswar -751014. Odisha
Corresponding Author: Saiprasanna Behera
ABSTRACT
Background- Scrubs typhus, an acute febrile illness caused by the bacteria Orienta tsutsugamushi which is a Rickettsia tsutsugamushi infection worldwide. During the 2nd world war, scrub typhus caused is the most common re-emerging Rickettsia tsutsugamushi infection, resulting in morbidity & mortality in the border region and other southeastern East Asia.
Methods-This retrospective study was conducted from 2015 to 2020 at AMRI Hospitals Bhubaneswar. A total number of 122 patient data was studied for this survey. Significant clinical findings such as fever. Jaundice, GIT symptoms were studied also including basic test parameters like renal profile, liver function test, respiratory, cardiac vascular, central nervous system dysfunction. The clinical data obtained were entered in Microsoft Excel-2019 later converted into a statistical package for social science (SPSS) 11.5 version for statistical analysis.
Results- Symptoms such as a high-grade fever, chills, shortness of breath, heart and vascular involvement, renal involvement, and jaundice are not the same as tropical fever. For an average day of fever, it was found that it lasted an average of 8 days. Two or more than two number of organ failures were shown to be the most common cause of death for patients. The duration of stay in the intensive care unit (ICU) is seven days, whereas the duration of stay on the general ward is eleven days. Acute renal damage (36%) and jaundice (38%) were also seen in 76 and 38 percent of patients, respectively. Acute respiratory distress syndrome, necessitating a non-invasive ventilator seen in 42% of patients hospitalized, whereas acute renal damage, requiring hemodialysis, accounted for 12% of patients admitted. Meningitis or meningoencephalitis is the most predominant manifestation of central nervous system. While heart failure, myocardial infarction, and ECG abnormalities were also found to be involved.
Conclusion- Scrub typhus is now among the most common causes of acute fibril illness in India. Scrub typhus is a re-emerging disease in India after decades. Early diagnosis and management is significant because there is a phenomenal reaction to treat with antibiotics which shall help in reducing mortality and disease complication from this infectious disease.
Keywords: Scrub Typhus, Orientia tsutsugamushi, Multiorgan dysfunctions, Early diagnosis.
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