Review Paper
Year: 2022 | Month: February | Volume: 9 | Issue: 2 | Pages: 33-39
DOI: https://doi.org/10.52403/ijrr.20220207
The Role of Intestinal Microbiome on Systemic Lupus Erythematosus
Norman Delvano Weky
Medical Doctor at Bhayangkara Titus Uly Hospital, Kupang, Indonesia.
ABSTRACT
Systemic lupus erythematosus (SLE) is one of the most common as chronic autoimmune disease with multiorgan target involved. The recent study found that commensal intestinal microbiome as trigger chronic autoimmunity in SLE that characterized by a significantly lower Firmicutes/Bacteroidetes ratio. It is related to activation inflammation mediators including toll-like receptors (TLRs), NOD-like receptors, adaptive immune response, and secretion of mucins antimicrobial peptides, defensins and immunoglobulin A. Other than that, lower of Firmicutes/Bacteroidetes ratio may induced activation of T helper cells and regulatory T cells, which both of these are significantly relationship in autoimmune activation for SLE. In nutrition approach for those SLE patient has been theoretically focused on the immunomodulatory effect of dietary components in the immune system activation, beside probiotic or prebiotic also significantly improve intestinal microbial related to SLE.
Keywords: intestinal microbiome, systemic lupus erythematosus, pathogenesis, autoimmune disease.
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