Review Article
Year: 2022 | Month: June | Volume: 9 | Issue: 6 | Pages: 1-10
DOI: https://doi.org/10.52403/ijrr.20220601
Prehyperuricemia: New Milestone in Metabolic Disorders
Dr. GR Subbu.1, Dr. Anita N.2, Dr. K Hari.3, Dr. Martin M.4
1Chief, Department of Medicine, St. Joseph's Hospital, Poovathussery, Parakkadavu.P.O,
Ernakulam - 693579, Kerala, India.
2Senior Physician, VPS Lakeshore Hospital, Ernakulam.
3Senior Physician, Aster Medicity, Ernakulam-682027.
4St. Joseph's Hospital, Poovathussery, Parakkadavu. P.O, Ernakulam-683579.
Corresponding Author: Dr. GR Subbu
ABSTRACT
The global population is living amid a metabolic explosion. The prevalence of hyperuricemia, as a metabolic disorder and a causal agent of non-communicable diseases, has been gearing up rapidly worldwide during the last two decades due to consuming a high purine diet, alcohol, red meat, high fructose-containing food, and lifestyle changes. The invisible bond between hyperuricemia and many non-communicable diseases is more robust than before. During the evolution of hyperuricemia, systemic inflammation develops, leading to endothelial dysfunction and end-organ injury. These molecular changes were not recognized previously. Hyperuricemia is now a metabolic, more clearly a vascular disorder than a crystallization disease. Asymptomatic hyperuricemia is no more benign, and gout is not synonym with hyperuricemia or vice versa. Diagnose hyperuricemia in an early stage at a high normal level and control it to prevent the development and complications of many hyperuricemia-related extra-articular diseases. For more acceptance and importance, this high normal level of serum uric acid can be named prehyperuricemia. As in the case of prediabetes and prehypertension, prehyperuricemia should be diagnosed early irrespective of age and sex; preventive measures have to be taken and maintain uric acid at a safer level.
Keywords: Serum uric acid, hyperuricemia, prehyperuricemia, high normal value of serum uric acid, metabolic disorder, non-communicable disorder, and molecular mechanism.
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