Research Paper
Year: 2022 | Month: June | Volume: 9 | Issue: 6 | Pages: 520-526
DOI: https://doi.org/10.52403/ijrr.20220655
Antioxidant Potential of White Turi Stem (Sesbania Grandiflora) in Reducing Malondialdehyde (MDA) and Blood Glucose Levels in Type 2 Diabetes Mellitus Model Mice
Putu Novi Handayani1, Ni Made Ayudia Shanty1, Ni Kadek Saras Dwi Guna1, Ni Wayan Sucindra Dewi 2
1Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia.
2Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia.
Corresponding Author: Ni Wayan Sucindra Dewi
ABSTRACT
Type 2 Diabetes Mellitus triggers hyperglycaemia conditions resulting in oxidative stress which is characterized by increased production of Reactive Oxygen Species (ROS) inducing in cell damage, resulting in lipid peroxidation which decomposes in the blood into Malondialdehyde (MDA). The use of natural antioxidants is believed to be safer and more effective in the long term. One of the plants that has a strong antioxidant content and activity is the White Turi Plant (Sesbania grandiflora). This study aimed to examine the antioxidant activity of white turi (Sesbania grandiflora) stem extract in reducing MDA and blood sugar levels in Type 2 DM model mice. A quasi-experimental method with an in vivo design was used in this study. A sample of 30 hyperglycaemic mice was divided into 5 groups: group K- was given aquadest and standard feed, group K+ was given glibenclamide 0.013 mg/20gBW, group I was given extract at a dose of 2.8 mg/20gBW, group II was given extract at a dose of 5, 6 mg/20gBW and group III was given extract at a dose of 11.2 mg/20gBW. At the end of the study, blood glucose and MDA levels will be measured as a biomarker of oxidative stress. Repeated measurement Anova and One-way Anova test was used in this study, it was found that white turi (Sesbania grandiflora) stem extract at a dose of 2.8 mg/gBW had an effect on decreasing blood glucose levels in mice. Moreover, based on the results of the MDA level test, it showed that there was an effect of white turi stem extract on reducing MDA levels in the blood of mice. In conclusion, white turi stem (Sesbania grandiflora) has the potential to reduce MDA and blood sugar levels in Type-2 DM model mice.
Keywords: [White Turi Stem (Sesbania grandiflora), Malondialdehyde, Blood Glucose, Reactive Oxygen Species, Diabetes Mellitus Type2] .
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