Original Research Article
Year: 2022 | Month: September | Volume: 9 | Issue: 9 | Pages: 398-402
DOI: https://doi.org/10.52403/ijrr.20220946
Correlation of Serum Uric Acid and Urine Uric Acid in Patients with Type 2 Diabetes Mellitus and Hypertension
Uthaya Sankar M K1, Rangarajan D V2, Rajagovindan D3, Swapna U S4
1Professor, Department of General Medicine, Sri Manakula Vinayagar Medical College, Puducherry
2,4Postgraduate, Department of General Medicine, Sri Manakula Vinayagar Medical College, Puducherry
3Professor And Head of The Department of Biochemistry, Sri Manakula Vinayagar Medical College and Hospital, Puducherry
Corresponding Author: Dr Rangarajan D V
ABSTRACT
Aims and objectives: To estimate the proportion of Hyperuricemia in patients with type 2 Diabetes Mellitus and Hypertension patients and to assess the correlation of serum uric acid and urine uric acid.
To assess the relationship between Urine Uric acid/ Creatinine ratio and subclinical Renal damage among these patients.
Materials and methodology: This cross-sectional study was conducted in Sri Manakula Vinayagar Medical College and Hospital Puducherry during a period of 6 months. Adults more than or equal to 18 years of age with Type 2 Diabetes Mellitus and Hypertension were included and a total of 56 patients were recruited. Patients were randomly included based on the inclusion and exclusion criteria
Results: Patients with Subclinical Renal damage were categorized and constitutes around 53.7%. Odds ratios on comparing the duration of Diabetes and Hypertension, shows inverse correlation with eGFR of both SRD and non-SRD patients (0.469,0.449 respectively) and with Urine Uric acid/ Creatinine ratio was found to have positive correlation (0.108 and 0.085). On comparing eGFR and Urine Uric acid/ Creatinine ratio of SRD and non-SRD patients, it showed positive correlation with value of 0.336.
Conclusion: Lower eGFR was associated with higher levels of Serum Uric Acid and Fractional excretion of uric acid (FEUA), but lower uUA/Cr levels. Thus this study suggests that urinary Uric Acid excretion was significantly associated with the risk of Subclinical Renal Damage and Urinary Uric acid can be used as a simple, noninvasive marker for early detection of decreased renal function in otherwise healthy subjects.
Keywords: Subclinical Renal Damage, Urinary Uric Acid, Fractional Excretion of Uric Acid
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