Year: 2024 | Month: November | Volume: 11 | Issue: 11 | Pages: 620-627
DOI: https://doi.org/10.52403/ijrr.20241164
CCL-2 as a Potential Biomarker for Neuropathic Pain in Leprosy: A Literature Review
Hermawan Hanjaya1, I Putu Eka Widyadharma2, Ketut Widyastuti2
1,2Neurology Department, Faculty of Medicine, Udayana University / Prof. Dr. I.G.N.G. Ngoerah General Hospital, Bali, Indonesia.
Corresponding Author: Hermawan Hanjaya
ABSTRACT
Neuropathic pain is a debilitating symptom in leprosy patients that significantly impacts their quality of life. While the mechanisms underlying this pain remain unclear, recent research suggests a potential role for C-C motif chemokine ligand 2 (CCL-2), a chemokine involved in inflammatory processes. This literature review explores the association between CCL-2 levels and neuropathic pain in leprosy patients. We discuss the current understanding of CCL-2's role in nerve damage and inflammation, as well as its potential as a biomarker for predicting and monitoring neuropathic pain in leprosy. Understanding the role of CCL-2 in leprosy-associated neuropathic pain may lead to the development of novel therapeutic strategies and improve the management of this chronic condition.
Keywords: CCL-2, neuropathic pain, leprosy
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